In Pen Tablet settings (driver app for Artist22E) click ‘Supports Digital Ink’ Open Toon Boom and go to Edit > Preferences > Advanced, turn on ‘Use QT Wintab Tablet Support’ Scaling performed by: Application’ and ‘disable fullscreen optimizations.’ ( not sure these did anything but reduce lag, but it’s working so I’m not messing with it.
Right-click Toon Boom > Properties > Compatibility – turn on ‘Override high DPI scaling behavior. I got it to work perfectly with the following settings in Windows 10: Unfortunately, like many others on the internet, I found that the pressure sensitivity did not work in Toon Boom, among other bizarre behaviours. I recently got an XP-Pen Artist 22E and I love it.